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Factor XI Deficiency |
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Factor XI Deficiency |
| This hereditary disorder occurs primarily in Jews of eastern European ancestry, resumably because intermarriage within this closed group, generation after generation, allowed the defective gene to surface more frequently. In the United States, for example, most cases are found in New York and Los Angeles. Approximately 200 cases of Factor XI deficiency have been reported since it was identified in 1953.
Most patients with Factor XI deficiency have little or no bleeding. Often there is no correlation between bleeding episodes and the level of factor. If you have factor XI deficiency, chances are your symptoms are milder than those of either haemophilia A or haemophilia B and there may be no strong relationship between your factor XI levels and bleeding complications. You may be prone to bruising, nose-bleeds, or blood in your urine. Prolonged bleeding after childbirth can occur. But you are not likely to bleed spontaneously, and haemorrhage is usually a problem only after an injury or surgery. Joint bleeds are uncommon, but delayed bleeding (starting an unexpectedly long time after an injury) may be a problem. |
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