 |
Factor X Deficiency |
|
Factor X Deficiency |
| Factor X deficiency ranks with Factor II as one of the rarest inherited clotting disorders, with only about 50 reported cases. Some cases are due to reduced or absent synthesis of the molecule; in other cases, the number of molecules is normal, but they don’t work properly. Several genetic variations of Factor X deficiency of varying severity have been described.
People with factor activity that is less than 1% of normal are susceptible to severe bleeding; those with 10% or more are only mildly affected. Symptoms include frequent bruising, gastrointestinal bleeding, and nosebleeds. Muscle and intracranial bleeding may be severe. Women with Factor X deficiency may have excessive menstrual bleeding and are susceptible to first-trimester miscarriage. Bleeding episodes are usually managed by infusion of fresh frozen plasma or PCCs. |
. .. . .
