Factor VIII
Treatment Guidelines
Treatment products may change:
read package insert. Patients with inhibitors
require special treatment.
Factor VIII
Treatment Guidelines
Treatment products may change:
read package insert. Patients with inhibitors
require special treatment.
| F VIII replacement for haemophilia A, no inhibitor.
Dose depends on bleeding severity. MINOR BLEED: 15-25 u/Kg MAJOR BLEED: 40 u/Kg Expected response: 1 u/Kg = 2% rise in F VIII level. Half-life F VIII: 8-12 hr. For serious bleeding F VIII assay may be required to monitor response to infusion.Inhibitor assay from the Haemophilia Centre may be important to guide therapy. |
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The Haemophilia Treatment Centre physician chooses which product is best for each patient. Please follow recommendations. Plasma-derived F VIII is treated with heat or solvent/detergent to inactivate viruses. Monoclonal antibody purification is used in some concentrates. (Recombinant VIII has been licensed in RSA) Round off dose to the nearest vial; do not discard excess F VIII. Repeat doses may be required, depending upon the severity of bleeding: always needed for major bleeds. |
